Daniele De Rossi looks set to miss out with a calf injury but defender Mattia De Sciglio is ready to return from a thigh problem.
Uruguay may name the same side that beat England, with Luis Suarez fit to start once again.
Captain Diego Lugano remains an injury doubt, but Maxi Pereira is unavailable once again after suspension.
BBc reports that the italian coach is under pressure going into this fixture.
DATE: June 24, 2014
TIME: 17:00 BST
VENUE: Estadio das Dunas, Natal
POSSIBLE LINE UP:
ITALY: Buffon; Bonucci, Chiellini, Barzagli; Darmian, De Sciglio; Pirlo, Verratti; Marchisio; Immobile, Balotelli.
URUGUAY: Muslera; Fucile, Gimenez, Godin, Caceres; Arevalo Rios, Gargano, Stuani, Rodriguez; Cavani, Suarez.
